What P2181 usually means
P2181 is broad on purpose. The controller is not accusing one neat thermostat or one perfect sensor circuit. It is saying the whole cooling-system story is not tracking the model the ECU expects. That can mean the engine warms too slowly, runs too hot in traffic, struggles with fan operation, traps air, or has coolant flow that no longer matches sensor behavior. The value of P2181 is that it pushes you to judge the full temperature pattern instead of replacing a thermostat just because that is the most famous cooling part.